The Nobel Prize for Literature laureate Ms. Pearl S. Buck lived in China for nearly 40 years and had a deep bond with China. This chapter focuses on the search for Ms. Pearl S. Buck’s imprint in China. It introduces Ms. Pearl S. Buck’s self-reported experiences in China and her feelings for China, pays a visit to her former residence in Zhenjiang, reviews the story between Ms. Pearl S. Buck and Chongshi Girls’ School, and explores the value and connotation of her work The Good Earth by looking at Ms. Pearl S. Buck through time and space. It gives a particular introduction to the contribution of Ms. Pearl S. Buck to the cultural exchange between China and the West.