The "Belt and Road" initiative has achieved remarkable success over the past ten years. Among them, the operation and running of the "China-Europe Railway Express" can be regarded as an exemplary and benchmark project for the construction of the "Belt and Road." Since its inception, the China-Europe Railway Express has received widespread acclaim and active participation from the international community, becoming a highly esteemed international public asset. It has not only reshaped the dynamics of international transportation between Asia and Europe but also established a novel platform for economic and trade collaboration along its route. The China-Europe Railway Express has emerged as a potent international logistics brand, characterized by significant radiance, driving force and influence, as well as navigates a developmental path marked by consensus-building, mutually beneficial cooperation, and vibrant dynamism, effectively bridging the realms of mutual connectivity and reciprocal advantages between nations in Asia and Europe. With data verification, multimedia teaching, case analysis, and other teaching methods, this course enables students to not only learn about the background and operation of the China-Europe Railway Express but also gain a deep understanding of its significance, its impact on China and countries along the route, and the profound implications of the "Belt and Road" strategy.